The following is a regular model that
we follow for a Comprehensive Complex Neuropsychiatric
Evaluation in CHIT. It includes several time based
interviews allowing a longitudinal perspective with
several cross-sectional views including Detailed History;
Physical and Neurologic Examination; Mental status
and cerebral cortical examination; Testing including
ASH, MMPI, SCL-90, INSET, BROCAS SCAN, FMMSE, NRBRPS;
and Electroencephalography and Labs, as required.
The patient is seen on several occasions
(usually 4 to 6) for comprehensive consultation.
On the first meeting, the major focus
is the main complaint, focus of referral, a detailed
pharmacologic history, history of investigations and
of associated features.
On the second meeting more details
about medical history are obtained, as well as physical
and neurologic examination.
The third evaluation includes integration
of test results and provisional diagnosis.
The fourth evaluation stresses recommendations
and pharmacologic treatment options and also included
feed-back.
Further consultations have a focus
on symptom and etiology removal through psychopharmacologic
integration and / or responsiveness as well as any
further details pertaining to tests or clinical information
that have come to light lat$
Mental status is assessed on each occasion.
At the conclusion, an extremely detailed
report is produced reflecting historical data, medical
evaluation, examination of higher brain functions
and investigation information. This allows for a detailed
multi-axial neuropsychiatric diagnosis and a road-map
for present and future management both pharmacologic
and non-pharmacologic. To facilitate the report being
properly read, whereas all areas may be important,
areas in italics or emboldened as well as table sections
on investigations, pharmacology and diagnosis and
the recommendations headers allow quicker initial
perspective on our findings.
The following order of the report is
followed which reflects information obtained, mostly
following a solid medical and psychological history
and examination model.
This is described in the patients
own words as well as then elicited listings and
details of the main complaints of patient. This
follows with
- History of main complaint,
- Age of onset of each problem including the
CHIT,
- History of current and past functionality,
- Family history both psychiatric and neurologic,
and the
- Patients self-perceived positive strengths:
-
A Special Investigation History
follows: Specifically elicited are details on
previous investigations such as EEGs,
MRIs Head, CTs Head, SPECTs Head, PETs Head, Spinal
tap, Neuroradiological procedures in the neck and
back, Electromyography and nerve conduction studies,
Electrocardiograms, Polysomnography, MMPI, and Neuropsychological
Testing. When available, source material is examined.
These tests often suggest that the CHIT was not
the first major neuropsychiatric event the patient
encountered.
-
Blood and urine tests are
ordered during the course of the evaluation unless
they have been done. The following blood tests
are the most usual procedures in CHIT, often done
to eliminate or diagnose alternative or additional
conditions. Erythrocyte sedimentation rate, glucose,
serology and HIV status, renal functions, electrolytes,
complete blood count, vit B12, folate, electrolytes
(sodium, potassium, chloride, magnesium, bicarbonate,
calcium, phosphate) hepatic functions, lipid profile
(cholesterol, triglycerides, LDL, HDL) and neuroendocrine
status including thyroid functions (TSH, thyroxin
and T3) and sometimes adrenal status (cortisol),
and pituitary and gonadal screens (Prolactin,
FSH, testosterone). It is usually sufficient to
test the patients urine biochemically at the office
level for protein, glucose, ketones, pH, blood
and bilirubin. If these are normal, and the patient
has no genito-urinary symptoms, one need not progress
to sending urine specimens away for cell examination
and microscopy, culture and sensitivity.
-
Pharmacologic history is
the next critical area. Current medications are
listed and these frequently on first interview
have not been prescribed by the evaluating physician
complicating interpretations because there is
a need to rely on the patient or family as a historian.
This constitutes a record of other
medications for baseline and information purposes.
The duration of each, onset of prescription, varied
dosages, and combinations at varied times in the
recent past are elicited. Degree of responsiveness
and side-effects are critically detailed and onset
and offset of these effects noted. Later interpretations
as to whether events were drug related are made
. Family history of response and non-response to
specific medications as well as allergies and side-effects
are also listed. Differentiation of generic and
trade preparations is made. The pharmacologic history
ultimately leads to the most critical single determining
factor for recommendations so that this is done
in great detail. A similar process is followed for
spontaneously eliciting information pertaining to
what the patient previously was taking. From this
the patients and also family members opinions are
elicited as to what medications the client did best
with and did worst with historically.
Thereafter the patient is asked to
complete a rather lengthy questionnaire listing
all known commonly used psychotropics, pain medications,
hormones, anticonvulsants and muscle relaxants and
even asking about experimental agents. Known common
side-effects are asked about as well as any positive
responses to medication. Dosage, duration of treatment
and therapeutic effects are also emphasized (Table
C).
Again responsiveness and compliance
is elicited with regard to each medication as well
as general impressions of best responsiveness and
improving compliance.
-
Nonprescription and Recreational
Drug Abuse history is then elicited using
the same principles as before. Duration, combinations,
dosage, effects both good and bad, side-effects,
compliance, addictiveness and dependency issues
are all asked about. Relevant is the way the patient
handled the specific recreational drug and whether
this may have predisposed to the CHIT or its consequent
severity.
-
Nonprescription drugs specifically
asked about include all the varieties of Marijuana,
LSD, amphetamines, mescaline, cocaine, phencyclidine,
heroin and narcotics. Additionally, critical to
the evaluation is the impacts of alcohol, caffeine,
cigars, pipes, cigarettes and other more socially
acceptable, legal drugs of abuse.
All the information above is generally
elicited on first interview. Later consultations
commonly amplify such information.
-
Neuropsychiatric symptomatology
is then evaluated. Originally the measuring instrument
used was the Neppe Temporal Lobe Questionnaire
derived from researching the symptoms of Temporal
Lobe Dysfunction from the literature as most of
the major historical organic brain symptoms as
opposed to physical signs derive from or impinge
upon the temporal lobe. This was later revised
to a new instrument which we routinely use on
all patients namely, The
INVENTORY OF NEPPE
OF SYMPTOMS OF EPILEPSY AND THE TEMPORAL LOBE
(INSET ). This is a paper and pencil test
and amplified by a detailed face-to-face interview.
The INSET involves screening for possible temporal
lobe, epileptic and organic symptoms and spells.
Thereafter the symptoms are categorized into several
headers namely nonspecific symptoms, possible
and controversial temporal lobe symptoms, seizure
related and other focal features. The test is
based on the subject and / or his family responding
to questions which are thereafter elaborated in
greater clinical detail. The
INSET
is copyrighted instrument.
The INSET plus medical history are
major determining factors as to whether to order
follow-up specialized electroencephalograms such
as an ambulatory EEG in the CHIT patient.
-
Examples of uncommon paper
and pencil neuropsychiatric instruments:
The Narcolepsy
Screen and
Déjà Vu Questionnaires
We have also developed several less
commonly used paper and pencil neuropsychiatric
instruments which are applied when appropriate.
One is the Neppe narcolepsy screen which
has not been well researched. Narcolepsy is a rare
condition itself (incidence possibly 1 in several
thousand individuals). However, the questionnaire
is far more versatile probing sleep disturbance
as well as anomalistic experiences and these are
common in the CHIT patient. Unfortunately, the questionnaire
needs to be scored by paper and pencil at this stage
and there are no norms so that although highly relevant
history information is obtained at a clinical level,
a clinician needs to interpret the results.
The Neppe Déjà vu
Questionnaires are other screening history instruments
seldom used in clinical practice. However, the major
value of this well validated instrument is to demonstrate
how we cannot interpret symptoms not elicited in
detail as the same. Using a phenomenological analysis,
Neppe was able to demonstrate that the symptom of
déjà vu, commonly regarded as symptomatic
of temporal lobe epilepsy indeed had a very special
phenomenologic quality in patients with temporal
lobe epilepsy (Neppe, 1983A). This involves its
association with post-ictal features such as sleepiness,
headache and clouded consciousness and its link
in time with these features. This association provides
an excellent clue to the existence of temporal lobe
epilepsy but déjà vu is a normal phenomenon
occurring in 70 percent of the population and unless
such phenomenological detail is obtained, patients'
symptomatology may be misinterpreted (Neppe, 1983
A). Neppe has similarly done such a study with olfactory
hallucinations (Neppe, 1983 B, 1984). A specific
type of temporal lobe epilepsy olfactory hallucination
could not be demonstrated although there were suggestive
features.
A major message, therefore, may be
the relevance of adequately assessing in detail
the symptomatology of patients presenting with CHIT.
If déjà vu occurs, temporal lobe epileptic
déjà vu must be specifically sought.
Such detail may be as relevant as electroencephalographic
monitoring (Neppe, 1983 A ).
-
Historical Base The next
consultation interview series focuses on increasing
data bases obtained by questionnaires and computers.
This develops the longitudinal perspective of
change over time, again essential in head injury
patients to understand predisposing features.
Any program involving detailed historical
and medical responses should be adequate.
These produce an automated report
and significant time is then spent checking data
and amplifying all positive information. The automated
report has significant limitations, partly due to
the way the answers in the ASH program are written,
as well as insufficient detail. Particular attention
should be paid to clarifying for example current
and previous misuse of recreational drugs. Moreover,
this cautious interpretation in regard to histories
of alcohol and drug use sometimes produce automated
interpretations based on group symptoms which can
be misconstrued where patterns of behavior unrelated
to alcohol or drug use may be misinterpreted as
linked.
Results are then combined in general
with additional tests and further detailed clarification
done thereafter.
The responses should be interpreted
with care as the questions asked are broad and the
possibility exists of incorrect information particularly
as patients may not be computer sophisticated or
may make errors in answering paper and pencil forms.
This is another reason for checking all positive
data.
-
PSYCHOLOGICAL AND PSYCHIATRIC
DIAGNOSTIC EVALUATIONS:
At this stage, the evaluation shifts
to more formal standardized evaluations. Routinely
at our institute, we evaluate patients using two
computerized psychological instruments - The MMPI
or its adolescent version - and the Symptom Check
List 90. There is strong support to use personality
evaluations and some would debate the Millon Clinical
Multiaxial Inventory (MMCI) should be used instead
of or in addition to the MMPI. We believe it useful
to screen current psychological symptoms hence the
use of the SCL 90. We do not find this an ideal
instrument and recognize its significant limitations
both in lack of detail and selectivity of questions.
Both these tests are not well standardized in the
brain injured populations but with the INSET and
other organic screens (e.g. BROCAS SCAN below) we
believe they are valuable. We have also considered
adding the SCID to our instrumentation. We precede
the test discussions with some background.
Assessment of Personality
Within the head trauma population,
perhaps the area that is the most difficult to understand
for both patient and provider, and often the most
complex, is the assessment of personality. Early
research in this area (Thomsen, 1974) revealed that
families of head trauma patients reported changes
in personality to be more of a burden to them than
residual physical problems. Goethe and Levin (1984)
conclude that family complaints about head injured
patients center around personality and behavior
changes rather than physical disabilities, and family
tensions typically increase as time goes even up
to two years following an injury.
Assessing potential changes in personality
obviously cannot be accomplished properly within
an hour or hour and a half diagnostic interview
with the patient. Understanding the subtle yet complex
changes that can occur in personality dynamics following
head trauma is primarily the basis for advocating
a time based evaluation process. Far too often misdiagnosis
is made with respect to the presence or absence
of personality disorders. As clinicians, we simply
need to humble ourselves and not be so quick to
make clinical judgments based on limited time with
the patient.
From the time period of the 1970s
through the 1980s the epidemiological, neurological
and neuropsychological evaluation of minor traumatic
head injury has produced a greater awareness of
the changes that can occur in intellectual and cognitive
functioning (OHara, 1988). Within the last five
to ten years there has continued to be research
generated on the definitions and neuropsychological
aspects of minor head trauma (Kibby & Long,
1996, Esselman & Uomoto, 1995, Cohadon, Richer,
& Castel, 1991, Alves, Macciocchi & Barth,
1993, Lowdon, Briggs, & Cockin, 1989). There
has however, been much less research and clinical
literature written on the neuropsychiatric aspects
of head trauma. McAllister (1992) discusses neuropsychiatric
sequelae of head trauma in terms of pathophysiology,
cognitive sequelae, behavior, effects of age, and
treatment. Also within the past five years, studies
emphasizing personality issues following head trauma
have increased our awareness of the need to understand
this aspect of the head trauma spectrum (Middleboe,
Birket-Smith, Anderson, & Friis, 1992, Miller,
1992). There is a great need within the health profession
to appreciate the subtle, yet significant changes
in personality that can occur with head trauma,
and to get beyond the purely clinical aspects of
assessing these changes to recognize the trauma
to the self. Clinicians who work day in and day
out with head trauma patients will attest to the
difficulties these patients experience when their
equilibrium of self has been altered by trauma and
brain injury.
In addressing this issue, it must
be reiterated again that to fully evaluate these
changes in personality takes time. Initially, the
patient is often preoccupied with problems with
pain and they are not yet aware of changes in themselves.
As recovery progresses, there is more awareness
of the cognitive and psychological problems. When
patients begin to feel better physically, they attempt
to get back in the swing of things and this is usually
the time period when they begin to notice that they
do not feel the same. As cognitive sequelae resolve,
they return to work and reintegrate into social
and leisure activities. However, continued reduction
in tolerance, irritability, emotional volatility,
and mental and emotional fatigue are experienced
on a daily basis.
These subtle residuals are typically
difficult to assess in the clinical setting. Yet,
time spent with these patients will often reveal
the struggle they experience in trying to cope with
everyday life. They are constantly reminded by the
difficulties they encounter that they have changed
and that they feel different. There is often a longing
to be like they used to be and get their life back
to what it used to be. But the truth of the matter
is that many of these patients will never regain
the old self and be able to capture the sense of
being who they were.
Patients with more dysfunctional
personality styles often develop secondary psychiatric
problems, which can considerably complicate the
clinical picture. This psychological overlay is
often misjudged by inexperienced health providers
as simply a manifestation of a personality disorder,
when in fact it is a manifestation of impaired coping
and the expression of futility at being unable to
deal with life effectively. There is the constant
experience of reduced cognitive stamina even though
many frank cognitive symptoms have resolved. This
usually takes the form of inability to keep up with
the demands of life and inability to enjoy the process
of living. There is often an anhedonic experience
of going through the motions of living but without
the ability to fully enjoy life events. These patients
will often feel like they are on the outside looking
in and not really participating. They feel detached
and surrealistic about living.
Patients with a primary concussive
injury and patients with predominant posttraumatic
reaction can experience these changes in their sense
of self. As a starting point for adequately assessing
these issues it is usually helpful to have a psychological
consultation incorporating some standardized, objective
measures such as the MMPI-2 and the MCMI-III (Millon
Clinical Multiaxial Inventory). This is useful in
differentiating predominantly posttraumatic symptomatology
from postconcussive complaints. The MMPI-2 is helpful
in assessing primary features of psychological functioning
and can be supplemented with the MCMI-III to gain
a more in depth analysis of personality traits and
style. This can guide the clinician in how to approach
treatment. Patients with more extreme elevations
on the MMPI-2 are typically experiencing greater
distress and there may be a need for psychopharmacologic
intervention. Examining personality style from the
MCMI-III can give the clinician valuable information
on how the expression of symptomatology will be
seen by others and the relative strengths and weaknesses
in personality structure.
MINNESOTA MULTIPHASIC PERSONALITY
INVENTORY
Adult clinical system interpretive
report (based on several authors - we have been
using Butchers broad interpretations and modifying
from there).
The MMPI-2 interpretation can serve
as a useful source of hypotheses about patients.
This report is based on objectively derived scale
indexes and scale interpretations that have been
developed in diverse groups of patients. The personality
descriptions, inferences and recommendations still
need to be verified by other sources of clinical
information since individual patients may not fully
match the prototype. Moreover, the interpretations
are based on statistically quantified results and
every individual is different enough to allow only
relative norms. Some of the questions of the MMPI
are difficult to answer yes or no to which further
complicates individual interpretation. Additionally,
diagnostic hypotheses generated by the MMPI are
only relevant in the appropriate clinical context.
ADOLESCENT MINNESOTA MULTIPHASIC
PERSONALITY INVENTORY
Adolescent clinical system interpretive
report (again for example based on Butcher).
The Adolescent MMPI-2 interpretation
can serve as a useful source of hypotheses about
teenage patients age range 13 through 18. Outside
these ranges cautious interpretations should be
made with the awareness that the test is technically
invalid or of limited validity. This report is again
based on objectively derived scale indexes and scale
interpretations that have been developed in diverse
groups of patients and again need to be verified
by other sources of clinical information since individual
patients may not fully match the prototype.
SYMPTOM CHECKLIST 90-R (DEROGATIS)
The SCL-90-R is a multi-dimensional
self-report inventory developed by Leonard Derogatis.
It is designed as a screening instrument for psychopathology
in psychiatric, medical, and nonpatient populations.
The scoring profile is expressed in percentile rankings
across the ninety items and following this is the
Derogatis interpretation of scores. For patients
below age range 19 years, cautious interpretations
should be made with the awareness that the test
is technically invalid or of limited validity. Again,
the interpretations are based on statistically quantified
results and every individual is different enough
to allow only relative norms. Some of the questions
of the SCL-90 are difficult to answer which further
complicates individual interpretation. In our experience,
many patients are interpreted as having obsessive-
compulsive symptoms on this test probably far more
than are warranted. Additionally, diagnostic hypotheses
generated by the SCL-90 are only relevant in the
appropriate clinical context.
MCMI-III - The Millon
The MCMI-III can be a rich source
of information regarding how a given patient may
be contributing to the postconcussive or posttraumatic
syndrome by the way they may be reacting to their
injury and its effects. This clinical data often
gives valuable insight into areas of personality
vulnerability, which are usually attenuated after
head trauma. When used in combination with the MMPI-2,
a more comprehensive basis for understanding personality
issues can be laid, with hypotheses being made for
further evaluation.
It should be pointed out that traditional
interpretative approaches for the MMPI-2 and MCMI-III
are inadequate and often lead to erroneous conclusions
when applied to the head trauma population. Too
often, computerized printouts of MMPI-2 and MCMI-III
results are misused by clinicians unfamiliar with
the dynamics of head trauma, and these patients
are assessed inaccurately. Interpretation of these
psychological instruments should be made within
the context of background information, details of
the injury event, symptomatology, and collateral
information. Psychological assessment should be
considered a starting point and not the only source
of evaluation.
Using the MMPI-2 and MCMI-III are
also useful in understanding issues of symptom magnification
and exaggeration or minimization of symptoms. These
issues are usually inherent in medicolegal cases.
Both the MMPI-2 and MCMI-III can be helpful in detecting
a mind set towards over-reporting or under-reporting
symptomatology. Verifying these issues are difficult
and a conservative approach should be taken. Clinicians
should look to the overall case presentation when
making clinical judgment regarding the intentions
of a given patient during an evaluation process.
Under-reporting of symptoms can often
be related to the denial that is seen in patients
with head trauma. These patients are acutely aware
of problems in cognitive and psychological functioning,
but often minimize these problems, hoping they will
just go away. During a cursory initial clinical
interview, the clinician can be misled into concluding
that the patient is not in any significant distress,
when in actuality they are often presenting themselves
in a favorable light because it is too difficult
for them to admit to the type of symptoms they are
experiencing. Patients are often embarrassed to
admit to having problems in their cognitive functioning.
There is also a tendency to minimize problems with
irritability, emotional volatility and reduced tolerance,
as these problems may not be consistent with how
they would like things to be. When there is consistency
between psychological testing and clinical impression,
this issue can be the catalyst to initiate a realistic
acceptance of these problem areas so that recovery
can be further facilitated.
On the other hand, over-reporting
of symptomatology is a much debated issue whenever
there are potential sources of secondary gain such
as the case is in litigation. After ruling out other
possible explanations of extreme elevations in clinical
profiles from the MMPI-2 and less often the MCMI-III,
the clinician can often detect this mind set towards
exaggeration and be in a better position to explain
the basis of persisting symptoms. This issue is
almost always a part of the postconcussive spectrum
and should be thoroughly evaluated. More often than
not, patients may be magnifying symptoms rather
than outright malingering. In addition, many patients
magnify symptoms because of their need to convince
the clinician that they really are having a legitimate
problem. Intentional magnification of symptomatology
is far less common than typically thought of among
health care professionals and the legal community.
Again, it should be pointed out that clarifying
these issues takes time and the most valid and reliable
assessment of under-reporting or over-reporting,
regardless of the results of psychological testing,
is to see the patient over a number of sessions
to document the consistency of their symptom presentation.
-
Relevant medical history data:
A detailed screening medical history involving
specific medical systems such as neurologic, cardiovascular,
respiratory, genito-urinary, gastro-intestinal
, endocrine and musculoskeletal systems ( including
pains ) is then taken. Information in this regard
is based on any basic medical textbook and is
not further amplified here although, of course,
any positive features should be followed through.
Allergy history is also elicited as well as injuries
including the CHIT that may be the current main
complaint. For most patients this should be performed
by a medical practitioner although nurses and
physicians assistants often obtain this history.
The requirement is obvious but worth emphasizing
as often psychiatrists particularly ignore taking
a detailed medical history and miss critical information.
-
PHYSICAL EXAMINATION and
-
including NEUROLOGIC EXAMINATION:
A single physical examination, generally
on our second time based examination is then performed.
Factors which may vary from time to time, such as
labile blood pressure, tachycardic pulse, areas
of tenderness and limitations in movement may be
repeated on several occasions. The neurological
examination is particularly critical and part of
the physical examination.
-
MENTAL STATUS EXAMINATION:
Just as neurologic evaluation is
critical to finding subtle deficits, mental status
evaluation is the key to a successful psychiatric
evaluation and can reflect pathology that may be
symptomatic of the CHIT.
This is performed sequentially on
several occasions along the time based examination.
There are many different ways of
performing the mental status examination
in neuropsychiatry. No one technique is necessarily
better than another.
We approach mental status by making
sure the major aspects are prioritized. The special
structure involves mnemonics as a helpful means
to recall items otherwise forgotten.
In mental status evaluations, the
special skill is to be as flexible as possible.
Some mental status headings are ambiguous as you
can, for example, describe certain signs under a
person's appearance and very often, the same features
could equally well relate to the patient's affect
- the appearance of the patient may be sad and that
same sadness should be picked up with regard to
his emotions.
The mental status examination in
psychiatry is the equivalent of the physical
examination in general medicine. Both logically
follow the taking of a medical history. This
elicits as much information as possible and prioritizes
what needs to be evaluated; then you examine the
patient. There is a fundamental difference, however:
much of the psychiatric examination is performed
by taking a history - this is a special skill itself
as the two functions of history and examination
are therefore performed simultaneously and sequentially.
Often the mental status examination
is confused with history taking. For example,
when the patient gives historical information, he
may not admit to any hallucinations: this may or
may not be true; this is not part of the mental
status examination. It is part of the mental status
evaluation. It is clearly important to inquire
about hallucinatory experiences, but asking about
hallucinatory experience may get the response, "No,
I never hear voices," when the patient is floridly
hallucinating. The patient may or may not tell you
about the voices he is hearing. Alternatively, he
may describe voices he does not hear to ensure conscious
or unconscious gains like admission to hospital
(and a warm bed and caring environment) as well
as fulfilling dependency needs. In the CHIT patient,
where medicolegal facets are often relevant, particular
attention should be paid to possible dissimulation
or malingering.
We should distinguish between the
historical mental status evaluation, which consists
of the symptom cluster descriptions relevant
to mental status, and the mental status examination,
that component of evaluation often relating to the
historical data but eliciting physical signs
about mental status.
History taking involves probing.
This is often facilitated by basic techniques or
maneuvers that occur during the interview. Very
often, history-taking involves eliciting both symptoms
and signs: to do so, the skilled examiner, as required
by the demands of the situation, shifts his interaction
with the patient. This involves performing frequent
probes, and keenly observing the response that results.
These have both content and process components:
The single major mnemonic for mental
status is ACCLAIMED.
In the CHIT we evaluate the nine major subheadings
of ACCLAIMED. In these nine major subheadings, which
imply the essence of every facet of the mental status
examination. The order of this mnemonic was empirically
derived from the most logical direction to do the
mental status examination; it is not contrived with
headings made to fit the mnemonic. ACCLAIMED constitutes
a priority system for the larger of the headings
of mental status examination.
-
CEREBRAL CORTICAL AND NEUROPSYCHIATRIC
EVALUATION
No adequate screening evaluation
of higher brain function appears in the literature.
Screening evaluation of the head injured patient
using available bedside screening instruments is
limited at present. The most widely used test (Naugle,
1989), the Mini Mental Status Examination (FMMSE)
(Folstein, 1975), is quickly administered and requires
little training, but has little predictive power
for diagnosis or classification of coarse neurobehavioral
syndromes, and is not designed to detect mild cortical
deficits (Naugle, 1989 ). Half of the MMSE s 30
questions emphasize orientation and calculation;
focal pathology is not effectively screened. Only
30% of multi-infarct dementia patients (Babikian,
1990) and 68% of Alzheimer's dementia patients scored
below the recommended cut-off of 24/30 on the MMSE,
raising questions about the test's sensitivity (Galasko,
1990). Even more seriously, 85% were false-positive
for the diagnosis of dementia, raising questions
about its use in a geriatric community setting (Gagnon,
1990). The MMSE also correlates poorly with basic
everyday living skills (Katz ADL Scale)(Ferrell,
1990), education and intelligence level, right hemisphere
dysfunction, and mild cognitive dysfunction (Ferrell,
1990) (Gagnon, 1990) (Gurland, 1987).
CHITs, CHIPs, dementia, focal cerebral
cortical abnormalities, pseudo-dementia and other
coarse neurocognitive brain syndromes are frequently
evaluated using neuropsychological batteries such
as the Halstead-Reitan and the Luria-Nebraska. Neuropsychological
evaluation is often helpful in gathering a comprehensive
standardized sample of cognitive and intellectual
functioning. When the practical demands of practice
make it prohibitive to have a patient complete the
often lengthy neuropsychological testing process,
there is an alternative that is less formal but
clinically quite useful.
The BROCAS SCAN
The most promising such clinical
instrument is our bedside screening test, the Screening
Cerebral Assessment of Neppe (BROCAS SCAN) which we spent the late
1980s refining and the 1990s developing data on
and using. (Neppe, et al, 1992) (scoresheets Appendix
2A and 2B)
This is a test of higher cerebral
cortical functions used as a bedside screening instrument.
The BROCAS SCAN permits a quantified
behavioral neurologic examination by providing clinical
personnel with a focal and global assessment of
a patient's mental status. Focal assessments include
gnosis, praxis, and sensory-motor-reflex skills,
which are not adequately addressed by the MMSE and
bedside tests, including the Neurobehavioral Cognitive
Status Examination (NCSE) (Schwamm, 1987 ). The
BROCAS SCAN is a more valid and more sensitive indicator
of pathology than the FMMSE, results which we have
seen hundreds of times clinically over numerous
neuropsychiatric diagnoses, and also demonstrated
in our research (Neppe et al, 1992).
The BROCAS SCAN is readily learned,
administered, and scored and has high interrater
reliability (Neppe, 1992), even when administered
by psychology students. It is versatile -40% of
neuropsychiatric patients who had the BROCAS SCAN
were considered unable to tolerate longer neuropsychological
batteries (Neppe, 1992). A SCAN on patients with
CHITs should take 10 to 40 minutes. Screening questions
eliminate unnecessary follow-up when the item is
answered correctly.
The acronym "BROCAS" spells out the
relevant scoring categories. "B" is for behavior
rating: a revised form of the Brief Psychiatric
Rating Scale (BPRS) of Overall and Gorham (Overall,
1962) (Beller, 1984) - the NEPPE MODIFICATION OF
THE BPRS or NMBPRS (Appendix 3).
Despite the frequent use of the BPRS,
this is the least quantifiable category and the
only one requiring specialized assessment. The remaining
10 categories comprise the "ROCAS" profile: "R"
for recall and recognition, "O" for orientation
and organization, "C" for concentration and calculation,
"A" for apraxia and agnosia, and "S" for speech
and sensory-motor-reflex. Each ROCAS category is
scored from zero (no impairment) to 10 (gross impairment).
The 40 items which compose the 10 ROCAS categories
are tabulated on a two-dimensional score sheet (Figures
1a and 1b). The result is expressed as the BROCAS
profile (Behavior + ROCAS), which reflects clinical
and neuropsychiatric features.
The first half of the test are basic
screening items which compose the Core score; the
second half are subtle items which compose the Fine
score. A Total SCAN score, ranging from zero to
100, is the sum of the Core and Fine scores. Two
versions of the BROCAS SCAN, labeled "A" and "B",
allow for retesting without contamination. Scoring
involves the patient' s performance. A perfect score
is zero and the normal intelligence individual without
major psychopathology generally scores <15. The
maximum score for the very grossly impaired is 100.
Because the BROCAS SCAN test concentrates
on physical signs, areas of the cerebral cortex
such as the temporal lobe and limbic system involving
predominantly symptom profiles are not evaluated
in detail - this is done with the INSET evaluation.
Two validity scores are obtained:
the first is the raters validity scale (0 = highest
level of validity ; 4 = very dubious). The second,
the subjective validity scale is the patients ranking
of difficulty in such areas as anxiety, concentration
and language understanding, and uses the same items
as the raters validity scale. This is currently
used clinically and helps in that way give insight
into the patients perception of his / her illness.
Table E reflects two typical SCANs.
Column A reflects a normal profile
and Column B may reflect a patient with a CHIT three
months post-injury. Table F reflects the interpretations
on these patients.
MINI-MENTAL STATUS EXAMINATION
The subject's mini-mental status
examination score based on Folstein and McHugh (1975)
(FMMSE: /30) and adding the World score (5) (/30-35)
is usually done in our evaluations for comparison
only. Because this test is suspect for sensitivity,
specificity and reliability, it is listed here only
because of its common use. The scores alone should
not be used to base any clinical decision.
NEPPE MODIFICATION OF THE REVISED
BRIEF PSYCHIATRIC RATING SCALE:
NMBPRS
This test generally uses a 0-6 (occasionally
7) ordinal ranking scale of each of 18 basic items,
plus 3 cognitive (COP) items and an additional frustration
score). The original Overall and Gorham test has
been subject to numerous variations and used a great
deal in evaluating change in psychopathology scores
over time, although inter-rater reliability may
be questioned. In this instance, the frustration
score is an additional item not found in the usual
BPRS, and in addition to orientation, a score of
on the COP items - concentration, orientation, perplexity
- is developed for higher cerebral function. To
ensure greater scoring consistency than in the original
BPRS, the essence of each item is summarized on
a score-sheet and the criteria in the PANSS of Kay
and Fiszbein are used. Also, a "validity score"
based on whether particular items could be ranked
accurately is used as well as an Overall Clinical
Impression Score.
The NMBPRS as recorded involves several
assessments over each interview and observation
period during testing. The NMBPRS score may be more
exaggerated at times of evaluating distinct psychopathology
and in a non-structured environment, hence, our
tendency is to evaluate at a time based level and
put in several scores. A subtest interpretative
report is then prepared. Table G reflects the NMBPRS
results of the CHIT patient in Table E above.
From the data of the ROCAS and B
items (i.e. the BROCAS SCAN and NMBPRS scores) a
provisional attempt is made to analyze scores by
combining these profiles. Conclusions pertain to
evidence of organic brain dysfunction reflecting
frontal, parietal or temporal lobe disease, current
marked dynamic or psychopathologic elements, any
direct evidence for possible psychotic preoccupation
although this is not specifically focussed on, and
evidence of a generalized organic brain syndrome.
Finally, a global perspective of range of normal
limits or mildly, moderately and severely impaired
are made.
-
Movement disorder evaluation: The
STRAW
Movement disorders are not generally
of great significance in CHIT or CHIP but may be
so depending on impacts on different parts of the
brain. Moreover, many of these patients may be receiving
major tranquilizer (i.e. neuroleptic - also called
antipsychotic) medication, sometimes in small doses.
Organicity may predispose to tardive dyskinesia
and thus it would then be mandatory to do such an
evaluation for abnormal involuntary movements.
STRAW is an acronym for a new technique
of evaluating involuntary movements, particularly
tardive dyskinesia. Neppe developed the STRAW in
the early 1990s because of the non-availability
of adequate measures which would reliably differentiate
subtle differences in tardive dyskinesia, and which
could be easily scored within a 10% range by several
different raters.
The STRAW has two components, a timing
component and a severity component. The STRAW timing
system involves equal scores of 50 for activation
and rest. The key to the STRAW is the timed component.
The timing component is scored out of 100 based
on a time period using the criterion of presence.
Tremor and epileptic seizure are not included as
involuntary movements.
Half the time is at rest is the "S"
for sitting at rest while relaxed, not under stress
and standing - the score is a rest score. The five
evaluations during activity are each out of 10 making
up 50 for activity (the TRAW) loaded equally with
the 50 for rest (the S of the STRAW).
Three body sections are measured
for severity: the head, the axial skeleton, and
the limbs. Each body section is rated between 0
and 10 in severity . In practice, the most severe
of these three rankings is the one that is most
closely followed over a period of time for tardive
dyskinesia.
The STRAW timing system is multiplied
by the STRAW severity, giving a total score out
of 1000. It is thereafter divided by 10 to score
out of 100. This gives an index of both severity
and duration of particular physical signs. Table
H reflects a typical scoresheet of a CHIT patient.
i.e. no movements.
-
The PBRS:
The Problem Behaviors Rating Scale
of Neppe and Loebel (PBRS)
is only useful in the context of inpatients. Thus
it may have more relevance acutely in a CHIP or
in a situation of permanent sequelae. We have found
it particularly useful to monitor change closely
over time in that it is unambiguous and usable even
by nurse aids. It is still being researched, however.
The PBRS is a 33 item rating scale
developed for nurses and related professionals in
a nursing geriatric, neuropsychiatric or other inpatient
environment. This ranks patients behavioral changes
over a defined period of time (a day or a week).
Each scale scores range from a normal of 0 to an
extreme of 3 producing a total of 99 making a range
from 0 to 99 (or 100 with 1 more for inpatients).
These criteria are based on unambiguous clinical
mental status features using the mental status mnemonic
ACCLAIMED covering areas broadly translated under
appearance, consciousness and concentration, cognitive
function, localization of cortical pathology, affect,
insight and judgement, motivation and motoric elements,
ego environment interaction, and dangerousness and
disability. A copy is listed in FIGURE C.
-
Routine Electroencephalogram
(EEG) (both sleep and wake with activating
procedures such as hyperventilation and photic
stimulation in th$ absence of medical conditions
contra-indicating these) is a reasonable proc$
in CHIT given any possible temporolimbic features,
episodic nature of sympt$ and history of atypical
spells . Sleep records have been well demonstrated
$ likely find focal pathology than waking EEGs.
However, waking EEGs have a h$ up rate and sleep
EEGs cannot be interpreted without the wake EEG.
It is interesting that prior to the
development of the EEG (by the neuropsychiatrist,
Dr. Hans Berger in the 1930's) all seizure disorders
were classified with mental disorders (Neppe, Tucker,
1988A, 1988B, 1992). EEG technology remains rather
primitive and reflections of brain waves from the
perspective of analysis of psychopathology somewhat
limited. Nevertheless, the only definitive way of
demonstrating that a symptom or physical sign such
as, for example, an olfactory hallucination is definitely
epileptic, is the demonstration of correlates of
seizure phenomena on EEG, such as spike-wave paroxysms,
while the person is having that experience. This
is unusual unless the seizure phenomena are relatively
uncontrolled. Even in the event of them having such
an experience, the EEG correlate may not necessarily
be of a spike kind but depending on location, it
could be normal or show a marked slowing, with a
nonspecific theta rhythm generally of limited help
unless focal or a delta rhythm, which is frankly
abnormal unless the patient is asleep (theta is
4 to 7 cycles per second, delta is less than 4).
It is occasionally extremely difficult to localize
such features on scalp EEG even when firing is occurring
because symptoms may occur from the mesial temporal
or deep structures within the brain which do not
easily manifest on surface EEGs (Tucker, Neppe,
1984, 1988).
Special electrode placements
Special techniques have been used
to overcome the problem. One commonly used technique
was nasopharyngeal electrodes but the increased
yield with nasopharyngeal electrodes is insubstantial.
A second placement is sphenoidal electrodes which
unfortunately, requires time, expertise and discomfort
limiting availability. A recent new suggestion has
been the placement of electrodes on the buccal skin
surface in the area of the submandibular notch -
possibly as effective in picking up foci as sphenoidal
placements. Finally, cerebral cortical placements
during neurosurgery procedures may show firing,
for example, in patients with temporal lobe epilepsy
and psychosis, in the region of the hippocampus.
The direct placement of intracranial electrodes
shows how commonly spike firing may be occurring
in this area with no correlate of any kind on surface
EEGs (Neppe, Tucker, 1988A, 1988B, 1992).
Sleep EEG records
There are several methods that are
used for evoking electroencephalographic abnormalities.
Sleep records increase the potential delineation
of focal abnormality such as a temporal lobe focus
by approximately fourfold. The administration of
chloral hydrate, 1 to 3 grams as premedication prior
to the sleep record is useful as this induces little
change of significance in the electroencephalogram
and does not prevent the demonstration of focal
abnormalities. Certain medications should be particularly
avoided in this regard. The first is the benzodiazepine
group which may have by virtue of their very strong
anti-epileptic effects profound effects in normalizing
the EEG. Such effects at a receptor level may last
weeks even with the apparent short acting benzodiazepines
so that the yield of demonstrating epilepsy after
the patient has had benzodiazepines administered
apparently decreases substantially, although adequate
data in this regard is not easily available (Neppe,
1984). Photic stimulation and hyperventilation are
also important evokers of abnormality in EEGs.
-
Home Ambulatory Electroencephalogram
(EEG)
Developments in this regard have
been rapid over the past few years.EEG Telemetry
involves prolonged monitoring over periods of time
varying from 12 hours to 2 weeks while the patient
is generally confined to a particular room. Cable
telemetry, is most commonly used. This involves,
for example, a 25 foot cable connected to the EEG
montage on the patient's head. Very often no seizure
manifestations are picked up for prolonged periods
of time because seizures only occur paroxysmally.
Moreover, those patients evaluated in a specialized
center with EEG telemetry are invariably so atypical
that the hypothesized seizure originates deep within
the brain. The apparatus costs over $100,000 and
the costs involved in monitoring patients are thousands
per day at times for two weeks. Instead, home ambulatory
electroencephalograms are easily available (Neppe,
Tucker, 1988A, 1988B, 1992), (Neppe, Tucker, 1988A,
1988B, 1992).
Ambulatory Electroencephalogram
(EEG) with the patient not modifying medication
is a valuable test when the patient's symptomatology
needs to be monitored day and night in a natural
environment of home using computerized filtering
of artefact. The advantage of this technique is
to establish if any scalp electrode can detect events
such as atypical spells alerted to by pushbuttons
reflecting deep brain electrical activity. It has
limited availability at this point, however, but
our pick up rate for atypical spells and seizures
is high.
Recent advances in EEG technology
may ultimately change the whole perspective in its
use in psychiatry. Computerized EEG monitoring
allows breakdown of wave forms and allows correlation
with evoked potentials including cognitive evoked
potentials. It also facilitates demonstrations of
changes in particular areas of the brain which can
be easily delineated at a visual level. This should
prove to be a useful psychophysiological correlate
of psychopathology. Indeed, this may be the beginning
of an important new era. However, at this point
in time it is still experimental.
-
Other investigations: Structural
lesion investigations are sometimes necessary
during the acute phase to ensure that secondary
bleeding has not occurred. Usually, this is clear
based on neurologic deficits or deterioration
of some kind. However, if neuroradiologic anatomic
tests are not done in the first month, the likelihood
that abnormalities will be picked up are considerably
diminished. Thus depending on symptomatology,
neuroradiologic investigations such as Magnetic
Resonance Imaging (MRI) of the head may be a useful
consideration. The balance is one of cost versus
Computerized (CT) SCAN but the yield may be more
with MRI. Additionally, CT is accessible and indicated
when magnetic clips make MRI contra-indicated
and bony lesions or acute blood extraversations
exist. This should be done with contrast material
unless allergy contra-indicates. However, it cannot
as well demonstrate tiny lesions, lesions of the
pituitary (where gadolinium contrasting on MRI
should be performed), small vessel vascular disease
and white matter lesions such as demyelinating
and degenerative disease.
Functional lesions which are
not necessarily structural and detected on MRI or
CT may be found on Single photon emission computerized
tomography (SPECT). This will demonstrate differences
in regional cerebral blood flow and hot and cold
areas of hyperflow and hypoflow. The differences
in laterality and particular areas of the brain
may have great clinical significance but the interpretations
are limited by lack of adequate diagnostic base.
Tests such as Positron emission tomography
(PET) are still experimental, very expensive and
not easily available in humans.
Similarly, measures such as Computerized
EEG like BEAM or Spectrum measures involve technology
which has outstripped research which means clinical
meaning may be difficult to interpret.
-
SYMPTOM MONITORING
- The patient and family should monitor episodes
of symptoms of anger/ aggression/ irritability/
anxiety / depression / memory / distress level.
This will be based on a daily grade evaluation.
Patient -ranking and / or family
ranking is listed in a table under the headings
date, time, approximate duration, with severity
at a nil 0, mild 1, moderate 2, severe 3, profound
4 level.
Rank irritability, concentration,
memory
-
Overall ranking for the day:
Mark out of 10 every day (This is individualized
by the patient depending on impairments: one
patient chose the following: 10 excellent, 0
very poor. with: 10 going to the store - walking;
8 still little trouble; 1 very impaired but
can make coffee
-
A sleep chart may facilitate
sleep monitoring so as to establish progress.
The patient or family should list total amount
of sleep for a 24 hour period, ending in morning
on waking.
-
The patient should list time
of day when feeling worst eliciting diurnal
variations in depression and fatigue.
-
Collateral Information
We have stated previously that the
patient with head injury symptoms is likely to have
difficulty expressing their thoughts and ideas.
This may be due to expressive deficits, a reduction
In self awareness, or secondary to memory problems.
Many patients with postconcussive symptoms experience
a reduction in spontaneous word production and are
unable to communicate the full extent of the changes
in cognitive and psychological functioning. Patients
with expressive problems often come up short in
trying to explain the daily problems they are encountering.
There may be dysnomia, poverty of thought content,
and loss of their train of thought. This can result
in inadequate clinical information being given to
the health care provider, who in turn may under
diagnose due to the appearance of minimal symptom
presentation.
Concurrently, there may be an inability
to fully appreciate the extent of cognitive problems
or psychological changes. This can be due to denial
and/or loss of ability to be aware of self and to
engage in insightful introspection or self analysis.
This is often seen with the frontal dysexecutive
syndrome. These patients do not fully appreciate
the changes in cognitive and psychological functioning
that significant others are keenly aware of.
On the other hand, many patients
go through a phase of denial, where they minimize
their postconcussive problems and may present themselves
in the most favorable light. This is often the case
where patients have been inappropriately reassured
by medical personnel that they will be back to normal
within a relatively short period of time, or that
there is nothing to worry about, or that their symptoms
will gradually diminish with time and there is very
little that can be done to treat them. When they
continue to experience difficulty in cognitive functioning,
continue to have problems with pain, and are unable
to cope effectively, they experience cognitive dissonance
because of their belief that they should be improving.
They may deny or try to hide or minimize their difficulties
with the hope that it will just go away. There may
be embarrassment with regards to their cognitive
problems, irritability and emotional volatility.
These problems may often be obscured by the patient
telling others that they just dont feel well.
Most patients with head trauma symptomatology
experience memory problems. Impairments in memory
processing may be due to concussive injury or as
part of the spectrum of posttraumatic disorder or
depression. These patients simply forget how they
are doing from day to day. They may be experiencing
a multiplicity of problems, but are unable to retrieve
this information during the time spent with the
health care provider. This may lead to the impression
that a given patient is not experiencing any significant
problems because they have not been able to adequately
remember the instances of cognitive dysfunctioning
or emotional overreactivity on a day to day basis.
It is for these reasons that it is
crucial to interview significant others or acquaintances
who have known the patient for some time before
the injury and have been in regular contact with
the patient following the injury. Where possible,
these friends and family members should have had
routine contact with the patient before the injury
and be able to describe their premorbid behavior.
These individuals will be able to document any changes
that have taken place by way of their regular interactions
with the patient. This collateral information is
often more accurate than information given by the
patient. The clinician should be careful to ask
about physical, cognitive and psychological functioning.
The most important issue to establish is whether
or not the significant other or acquaintance has
observed changes in the patients behavior following
the traumatic event.
A review of the patients physical
functioning from someone who is around the patient
on a daily basis can provide valuable information
regarding the frequency, intensity, and duration
of complaints. It is important to ask about changes
in the patients sense of smell and taste, since
there is often a loss or partial loss of olfactory
processes. This is often an overlooked symptom in
the mild to moderate head injury population. Information
should be gathered as to any complaints the patient
may be making regarding more subtle changes in functioning
such as sensitivity to bright light (sunlight or
night driving), the sensation of obscurity to their
visual acuity, ringing in the ears, intolerance
to noise or distractions during active concentration,
problems with coordination and tactile dexterity,
poor proprioception, and sensation. Review of the
patients pain behavior is essential in understanding
the factors that may be influencing the experience
of pain.
During a review of the patients cognitive
functioning, the clinician should ask about situational
manifestations of cognitive problems. The clinician
needs to know how the patient is functioning across
different situations and within a variety of environments.
It is important to know if the patients cognitive
changes are obvious to others and whether or not
the patient is relying on others to compensate for
his cognitive difficulties.
Primary care group members should
be asked about the patients flow of thinking including
speed of information processing, attention and concentration.
The clinician should try to ascertain whether the
patient is able to maintain and sustain attention
and concentration and if there is distractibility.
Memory processing should be thoroughly evaluated
to establish a pattern of memory problems that is
specific to that patient. It is not enough to just
document the presence or absence of memory problems.
It is also important to review the patients problem
solving abilities, organizational skills, reasoning,
the ability to perform sequential activities and
make schedules and plan ahead. Mental arithmetic
reasoning should be asked about regarding the patients
ability to keep up with finances, make change, and
estimate necessary everyday calculations. The clinician
should ask about the patients ability to express
themselves, word finding difficulties, losing their
train of thought and the style of speech. The patients
comprehension and receptive language abilities should
also be reviewed including reading comprehension,
the ability to follow TV programs, and how well
the patient understands and responds to others.
Perhaps the most important reason
for obtaining collateral information is to document
and describe the changes in psychological functioning.
Head trauma patients typically are better historians
with respect to their physical functioning, but
have more difficulty describing changes in themselves.
Individuals who know the patient well are often
able to notice changes in mood and affect more readily
than the patient. It is important to know how the
patient is responding to stress. The clinician should
determine whether the patient is more irritable,
is less patient with others, has low frustration
tolerance and whether there have been episodes of
emotional volatility. Questions should also be asked
about frontal lobe behavior, especially increased
passivity or aggressivity. Routine questions should
also be included to asses other areas of psychological
functioning in consideration of secondary psychological
problems such as anxiety or depression.