Depression Related Lectures

Vernon M Neppe MD, PhD, FFPsych(SA), FRCPC

Combination serotonin antidepressant therapy

1. The development of a broader theory of innovative psychopharmacotherapy and the understanding of concepts such as neuromodulation and partial agonism.
2. To discuss the clinical and theoretical frameworks for enhancing the effects of SSRIs in cases of clinical refractoriness and side-effects.

Antidepressants, serotonin specificity and neuromodulation

1. The development of a broader understanding of why antidepressants succeed and fail when they do and what to do about it.
2. To educate in the area of serotonin in the context of clinical psychiatry.
3. To evaluate the serotonin 2 receptor with regard to management options and problems.
4. To elucidate a role for norepinephrine in relation to serotonin and depression.
5. To establish alternatives for lowering antidepressant side effects.
6. To develop a profile of the ideal antidepressant compound based on a pharmacologic model.

Modern frameworks for the management of depression: the new antidepressants

1. To educate in the area of depression and anxiety and to demonstrate areas of similarity and differences.
2. To discuss the clinical implications with regard to management options and problems.
3. The development of a broader theory of innovative psychopharmacotherapy and the understanding of concepts such as neuromodulation and partial agonism.
4. To educate in the area of serotonin re-uptake inhibition and the partial agonists in the domain of the clinical psychiatric context.
5. To discuss the clinical and theoretical frameworks for enhancing the effects of SSRIs in cases of clinical refractoriness and side-effects.
6. To develop a profile of the ideal antidepressant compound based on a pharmacologic model.

Innovations in the management of anxiety and depression in the female patient

1. To educate in the area of anxiety and depression and to demonstrate areas of similarity and differences.
2. To discuss the clinical implications with regard to management options and problems.
3. The development of a broader theory of innovative psychopharmacotherapy and the understanding of concepts such as neuromodulation using the bathtub analogy and partial agonism.
4. To discuss the clinical and theoretical frameworks for enhancing the effects of antidepressants in cases of clinical refractoriness and side-effects.
5. To focus these theories on the female patient with consideration of premenstrual, pregnancy, post-partum situations and the post-menopausal frameworks.

Antidepressants choosing, resistance, switching, combinations: the rest of the picture

1. The development of a broader understanding of chemical reasons underlying antidepressant response and side-effects
2. To educate in the area of serotonin and norepinephrine in the context of clinical psychiatry.
3. Examination of serotonin subtypes with regard to management options and problems.
4. To elucidate a role for norepinephrine in relation to serotonin and depression.
5. To establish alternatives for lowering antidepressant side effects.
6. To develop a profile of the ideal antidepressant compound based on a pharmacologic model.
7. To discuss models of shifting from SSRI therapy.

Insomnia, Psychiatric Disturbance and Antidepressants

1. To educate in the area of sleep and insomnia
2. To discuss the clinical implications with regard to management options and problems linked with psychiatry.
3. The development of a broader theory of innovative psychopharmacotherapy and the understanding of concepts such as receptor complexes
4. To educate in the nonpharmacologic management of insomnia.
5. To discuss the clinical and theoretical frameworks for the current hypnotic agents and antidepressants.

Hepatopsychiatry and antidepressants: P 450 and beyond

1. To detail the pharmacology of the P450 cytochrome system.
2. Discuss the relevance of antidepressants and drug interactions.

Serotonin neurotransmission: Implications for depression, anxiety and irritability

1. The development of a broader understanding of why antidepressants succeed and fail when they do and what to do about it.
2. To educate in the area of serotonin in the context of clinical psychiatry.
3. To evaluate the serotonin 2 receptor with regard to management options and problems.
4. To elucidate a role for norepinephrine in relation to serotonin and depression, anxiety and irritability.
5. To develop a profile for treatement based on a pharmacologic model.

Pharmacologic management of anxiety with depression

1. To educate in the area of anxiety and depression overlap.
2. To discuss the clinical implications with regard to management options and problems.
3. To discuss the role of neuromodulation in the brain and explanation of apparent paradoxes.

The new antidepressants: a perspective

1. A broader understanding of chemical reasons underlying antidepressant response and side-effects.
2. To educate in the area of serotonin and norepinephrine in the context of clinical psychiatry.
3. Examination of serotonin subtypes with regard to management options and problems.
4. To elucidate a role for norepinephrine in relation to serotonin and depression.
5. To establish alternatives for lowering antidepressant side effects in the post - SSRI era
6. To develop a profile of the ideal antidepressant compound based on a pharmacologic model.

Perspectives to the depressed medically ill / geriatric patient with depression

1. To evaluate problems of anxiety, depression and combinations in the older patient
2. To elucidate a role for norepinephrine in relation to serotonin and depression.
3. To establish alternatives for lowering antidepressant side effects.
4. To develop a profile of the ideal antidepressant compound based on a pharmacologic model.

© Copyright 1997 Pacific Neuropsychiatric Institute.